Innovative Solution: Mussel-Inspired Coating Material for Implants Fights Bacterial Infections

05-03-2024

(WorldKings.org) Collaborative Research Offers Promising Approach to Combat Rising Rates of Degenerative Arthritis in Young Adults

As cases of degenerative arthritis surge among young adults due to sedentary lifestyles and strenuous physical activities, a pioneering study brings hope with a novel solution involving mussels. Led by Professor Hyung Joon Cha from POSTECH and Dr. Hyun Sun Choi from Pohang University of Science and Technology (POSTECH), along with Professor Yun Kee Jo from Kyungpook National University, the research introduces a groundbreaking coating material for implants designed to release antibiotics in response to bacterial invasion.

Published in Biomaterials, a prestigious international journal, the study addresses challenges in implant procedures caused by bacterial infections. Current treatments often face hurdles such as antibiotic resistance and physical damage to the implant material. However, the team's innovative approach, inspired by mussel adhesion proteins, offers a promising solution.

In this research, the team directed their attention to DOPA, one of the amino acids found in mussel adhesion proteins. DOPA, crucial for the robust adhesion observed in mussels, forms potent bonds with metal ions. Its interaction with ferrous metal ions is notable because it weakens as the acidity (pH) decreases. Recognizing that bacterial invasion alters the body's acidity, the team developed a novel implant coating material.

This material contains antibiotics under normal conditions, but in the event of a bacterial infection and subsequent acidification, it releases 70 percent of the antibiotics within eight hours, effectively eliminating the bacteria. Notably, the material exhibits remarkable durability, showcasing immediate antibacterial efficacy even during the bone regeneration phase (approximately four weeks) following the implant procedure.

The quantity of antibiotics discharged by the material corresponds to the extent of bacterial infection, and the researchers additionally validated the antibacterial efficacy of the coating material based on varying bacterial concentrations. Particularly, the bond between DOPA and iron ions showed remarkable resilience to external physical stimuli, rendering it resistant to abrasion and mechanical loads encountered during the implantation process.

Professor Hyung Joon Cha emphasized the potential of the adhesive implant coating material to enhance the success rate of implant procedures. Professor Yun Kee Jo highlighted the significance of selectively releasing antibiotics, potentially preventing the emergence of superbacteria in the future.

Supported by various research grants, including those from the Ministry of Health and Welfare and the Ministry of Science and ICT, the study represents a significant step forward in combating bacterial infections associated with implant procedures. With further development, this innovative technology could revolutionize the treatment of degenerative arthritis and other conditions requiring implants, offering hope for a healthier future.

According to the Internet 


Esther (Collect & Edit) - WORLDKINGS (Source of photos: Internet)

 

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