1. Bill And Melinda Gates Foundation
This organization’s endowment is valued at $42.3 billion. It began operations as a private charitable organization in 2000 by channeling profits from the ownership of Microsoft, a global technology giant. Through donors and grants, the Foundation seeks to support innovative projects primarily in the areas of poverty, healthcare, and education. The organization serves the whole world and regularly collaborates with NGOs to alleviate the world’s most pressing concerns such as HIV/AIDS. Its healthcare budget alone exceeds that of the World Health Organization (WHO).
2. Stichting INGKA Foundation
Located in the Netherlands, the Stichting INGKA Foundation has assets worth $34.63 billion. The foundation was established in Leiden in 1982 by the Swedish billionaire, Ingvar Kamprad. Kamprad is the founder of the global retailer, IKEA. The organization is listed as the owner of INGKA Holding. Its philanthropic activities have recently been targeted towards refugees and children in the developing countries. The foundation partners with reputed NGOs such as the UN in developing programs which will have the most impact.
3. Wellcome Trust
The Wellcome Trust is the second wealthiest foundation in Europe with an endowment valued at $26.0 billion. It began operations in 1936 using capital left by Sir Henry Wellcome in his will. Sir Wellcome was a pharmaceutical entrepreneur known for founding Burroughs Wellcome &Company. The organization is headquartered in London, and it focuses on the field of biomedical research. The Foundation funds new drug discoveries and new medical methods. To inform the public, the foundation publishes free journals. The trust has funded research into such concerns as the Ebola virus and organ transplant.
4. Howard Hughes Medical Institute
The Howard Hughes Medical Institute is the second wealthiest charitable foundation in the US with assets valued at $18.2 billion. The organization has been operating since 1953 after being founded by Howard Hughes who is mainly associated with the Hughes Aircraft Company. The foundation primarily supports medical and biological research as well as education and science. It invests nearly $825 million in biomedical research annually. The Foundation supports outstanding students and scientists in different disciplines including genetics and neurosciences.
5. Ford Foundation
The Ford Foundation is an American private foundation with the mission of advancing human welfare. Created in 1936 by Edsel Ford and his father Henry Ford, it was originally funded by a US$25,000 gift from Edsel Ford. The Ford Foundation makes grants through its headquarters and ten international field offices. For many years, the foundation's financial endowment was the largest private endowment in the world; it remains among the wealthiest. According to the OECD, the Ford Foundation provided US$224.4 million for development in 2018, all of which related to its grant-making activities.
According to worldatlas.com and en.wikipedia