Pfizer

Pfizer Inc. is an American worldwide pharmaceutical enterprise. It is positioned 64 on the 2020 Fortune 500 rundown of the biggest United States Corporation on basis of total revenue. Headquartered in Manhattan, Pfizer develops and produces medicines and vaccines for a wide range of medical disciplines, including immunology, oncology, cardiology, endocrinology, and neurology.

In May 2020, Pfizer began testing four different COVID-19 vaccine variations. It planned to expand human trials to thousands of test patients by September 2020. The pharma company injected doses of the potential vaccine BNT162b2, which was developed by the German biotechnology company BioNTech, into the first human participants in the U.S. in early May. Based on the results, Pfizer said they "will be able to deliver millions of doses in the October time frame" and expects to produce hundreds of millions of doses in 2021.

Merck

Merck and Co., Inc., d.b.a. Merck Sharp and Dohme (MSD) outside the United States and Canada, is an American worldwide pharmaceutical company based in New Jersey. Medically significant antibodies created at Merck incorporate the first-ever mumps vaccine, the primary rubella vaccine, and the main trivalent measles, mumps, rubella (MMR vaccine).

Total market cap: $210.068 billion

Total revenue of the company: $46.840 billion

AstraZeneca

AstraZeneca plc is a British-Swedish multinational pharmaceutical and biotechnology company. Cambridge Biomedical Campus in Cambridge, England.It has a portfolio of products for major diseases in areas including oncology , cardiovascular, gastrointestinal, infection, neuroscience, respiratory, and inflammation. It is perhaps best known for its involvement in developing the Oxford-Astrazeneca COVID-19 vaccine.

Total market cap:$133.055 billion

Total revenue of the company: $23.565 billion

Johnson & Johnson

Johnson and Johnson (J&J) is an American global corporation established in 1886 that creates medical devices, consumer goods, and pharmaceuticals. It is viewed as a central participant in the COVID-19 vaccine race.

Total market cap: $421.312 billion

Total revenue of the company in 2019: $82.059 billion

Moderna

Moderna is an American pharmaceutical and biotechnology company based in Cambridge, Massachusetts. It focuses on drug discovery, drug development, and vaccine technologies based on messenger RNA (mRNA). Moderna's technology platform inserts synthetic nucleoside-modified mRNA (modRNA) into human cells using a coating of lipid nanoparticles. This mRNA then reprograms the cells to prompt immune responses. It is a novel technique, abandoned by other manufacturers due to concerns about the toxicity of lipid nanoparticles at high or frequent doses.

In November 2020, it was announced that the Moderna COVID-19 vaccine candidate (codenamed mRNA-1273), had shown preliminary evidence of 94% efficacy in preventing COVID-19 disease in a Phase III trial, with only minor flu-like side effects. This led to its submission for emergency use authorisation (EUA) as a COVID-19 vaccine in Europe, the United States, and Canada. On December 18, 2020, mRNA-1273 was issued an EUA in the United States. On December 23, 2020, it was authorised for use in Canada. On January 6, 2021, it was authorised for use in the European Union. On January 8, 2021, mRNA-1273 was authorised for use in the United Kingdom. On March 15, 2021, mRNA-1283 was started for the phase I clinical trial.

Total market cap: $44.616 billion

Total revenue: $94.47 million

According to in.finance.yahoo.com.