[Worldkings] Top 200 breakthrough research works in the world (P. 53) UNIST Institute makes great progress in scarless wound recovery using autologous blood (Korea)

09-09-2023

(Worldkings.org) A recent study has introduced a groundbreaking milestone in tissue regeneration by developing a technology that utilizes autologous blood to produce three-dimensional microvascular implants.

A research team, affiliated with UNIST has achieved a groundbreaking milestone in tissue regeneration by developing a technology that utilizes autologous blood to produce three-dimensional microvascular implants. These implants hold immense potential for various applications requiring vascular regeneration, including the treatment of chronic wounds.

Led by Professor Joo H. Kang from the Department of Biomedical Engineering at UNIST, the team successfully developed a microfluidic system capable of processing blood into an artificial tissue scaffold. Unlike previous methods that relied on cell-laden hydrogel patches using fat tissues or platelet-rich plasma, this innovative approach enables the creation of robust microcapillary vessel networks within skin wounds. The utilization of autologous whole blood ensures compatibility and promotes effective wound healing.

 

Credit: UNIST News Center

 

By harnessing the power of microfluidic technology, Professor Kang's team transformed autologous blood into IVETs (implantable vascularized engineered thrombi) suitable for transplantation. These IVETs were implanted into full-thickness skin wounds in experimental mice, resulting in rapid and scarless recovery of the entire damaged area. The study demonstrated successful regeneration of blood vessels within the wound site, facilitated movement of immune cells crucial for wound healing, and accelerated overall recovery.

Furthermore, the team evaluated the efficacy of IVET transplantation by infecting methicillin-resistant Staphylococcus aureus (MRSA) -- an antibiotic-resistant bacterium -- into the skin damage area. When artificial blood clots made from autologous blood were implanted into infected mice, quick vascular recovery was observed alongside enhanced migration of proteins and immune cells to combat bacterial infection. Additionally, collagen formation and hair follicle regeneration occurred without scarring.

These groundbreaking findings pave the way for advanced techniques in tissue engineering and wound healing using autologous blood-based implants. With further development and refinement, this technology holds tremendous potential to revolutionize treatment strategies for chronic wounds while contributing to advancements in regenerative medicine.

 

According to sciencedaily.com


Kyna ( Collect) - WORLDKINGS (Source of photos: Internet)

 

towerWorldKings journeys
islandvilalage
WCSA
ASEAN BOOK OF RECORDSASIA BOOK OF RECORDS
CAMBODIA BOOK OF RECORDSWorld Records University
worldmark