[WorldKings - Wowtimes - Almanac Events & Achievements 2023] Innovations of biotechnology group Seagen Inc. in 26 years of development (1997)


(worldkings) Seagen Inc. (formerly Seattle Genetics, Inc.) is an American biotechnology company focused on developing and commercializing innovative, empowered monoclonal antibody-based therapies for the treatment of cancer.

The company, headquartered in Bothell, Washington (a suburb of Seattle), is the industry leader in antibody-drug conjugates or ADCs, a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Antibody-drug conjugates are intended to spare non-targeted cells and thus reduce many of the toxic effects of traditional chemotherapy, while potentially enhancing antitumor activity.



The company’s milestones:

1997: Seattle Genetics was founded by Henry Perry Fell, Jr. and Clay Siegall, and is headquartered in Bothell, Washington, a suburb of Seattle.

1999: The company researched into anti-CD30 antibodies begins.

2001: The company’s scientists synthesize monomethyl auristatin E (MMAE), the cytotoxic drug payload for our first investigational antibody–drug conjugate (ADC), brentuximab vedotin (ADCETRIS®).

2006: The first clinical trial patient receives brentuximab vedotin (ADCETRIS).



2007: Seagen and Agensys (acquired by Astellas) enter into a collaboration, resulting in the co-development of enfortumab vedotin, an investigational ADC that targets Nectin-4.

2009: Seagen and Takeda agree to globally co-develop and commercialize brentuximab vedotin (ADCETRIS).

2011: ADCETRIS® (brentuximab vedotin receives accelerated approval in the U.S.

2015: Seagen expands access to ADC technology via collaborations with global biotechnology and pharmaceutical industry leaders.

2016: The company’s European headquarters opens in Zug, Switzerland.



2019: ADCETRIS is established as a foundation of care and approved in more than 70 countries.

2022: Pfizer agreed to acquire Seagen for a total enterprise value of around $43 billion.

According to en.wikipedia; seagen.com. Source of photos: internet 


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