[WorldKings - Wowtimes - Almanac Events & Achievements 2023] Innovations of biotechnology group Seagen Inc. in 26 years of development (1997)

18-12-2023

(worldkings) Seagen Inc. (formerly Seattle Genetics, Inc.) is an American biotechnology company focused on developing and commercializing innovative, empowered monoclonal antibody-based therapies for the treatment of cancer.

The company, headquartered in Bothell, Washington (a suburb of Seattle), is the industry leader in antibody-drug conjugates or ADCs, a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Antibody-drug conjugates are intended to spare non-targeted cells and thus reduce many of the toxic effects of traditional chemotherapy, while potentially enhancing antitumor activity.

 

 

The company’s milestones:

1997: Seattle Genetics was founded by Henry Perry Fell, Jr. and Clay Siegall, and is headquartered in Bothell, Washington, a suburb of Seattle.

1999: The company researched into anti-CD30 antibodies begins.

2001: The company’s scientists synthesize monomethyl auristatin E (MMAE), the cytotoxic drug payload for our first investigational antibody–drug conjugate (ADC), brentuximab vedotin (ADCETRIS®).

2006: The first clinical trial patient receives brentuximab vedotin (ADCETRIS).

 

 

2007: Seagen and Agensys (acquired by Astellas) enter into a collaboration, resulting in the co-development of enfortumab vedotin, an investigational ADC that targets Nectin-4.

2009: Seagen and Takeda agree to globally co-develop and commercialize brentuximab vedotin (ADCETRIS).

2011: ADCETRIS® (brentuximab vedotin receives accelerated approval in the U.S.

2015: Seagen expands access to ADC technology via collaborations with global biotechnology and pharmaceutical industry leaders.

2016: The company’s European headquarters opens in Zug, Switzerland.

 

 

2019: ADCETRIS is established as a foundation of care and approved in more than 70 countries.

2022: Pfizer agreed to acquire Seagen for a total enterprise value of around $43 billion.

According to en.wikipedia; seagen.com. Source of photos: internet 

 

Bee (Collect) - WORLDKINGS (Source of photos: Internet)

 

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