Evan was born in Los Angeles, California, to Melissa Ann Thomas and John W. Spiegel, both lawyers. Spiegel grew up in Pacific Palisades, California. He was raised Episcopalian. He was educated at the Crossroads School for Arts and Sciences in Santa Monica, and attended Stanford University.
Spiegel took design classes at the Otis College of Art and Design while still in high school and at the Art Center College of Design in Pasadena the summer before entering Stanford. He also had an unpaid internship in sales at Red Bull. While a student, he worked as a paid intern for a biomedical company, as a careers instructor in Cape Town, South Africa, and at Intuit on the TxtWeb project. Spiegel was a member of the Kappa Sigma fraternity
In 2012, Evan left Stanford to focus on Snapchat shortly before completing his degree. While studying product design at Stanford he proposed Snapchat as a class project. Spiegel co-founded the mobile application Snapchat along with Robert Murphy and Reggie Brown. He is the CEO of Snap, Inc